Resolute Science: Targeting Macrophages to Treat Glioblastoma

Novel Approaches and New Therapeutic Platforms

Faith Barnett, MD, PhD

Andre Basbaum

Annually, approximately 250,000 people worldwide succumb to glioblastoma (GBM), with a median survival time of just 15 months post-diagnosis, despite treatment. The disease’s complexity leads to near-inevitable recurrence and a dismal 5-year survival rate of 5-7%. Moreover, GBM progressively impairs neurological functions, severely affecting quality of life. Resolute Science is advancing RS-5 and RS-8, two first-in-class therapeutics that leverage our Macrophage-Targeted- Conjugates (MAC-TACs) delivery platform. The most promising candidate will be selected for clinical trials targeting glioblastoma. We anticipate that successful validation of either RS-5 or RS-8 could introduce a groundbreaking treatment option for GBM, offering a safer, and more effective therapeutic to patients who are currently without options.

“Resolute Science’s goal is to provide cancer cures for more people. We are extremely grateful for Curebound’s support & funding, which will allow us to accelerate our preclinical research into brain tumors and GBM specifically.” – Faith Barnett, MD, PhD